OA: Genomics of (sporadic serous) Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube

open access: Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube | Cancer Discovery
 

The data presented herein may lead us to develop our perception of STIC further: STIC in HGSOC could be primary or metastatic. Previous studies observed precursor lesions exclusively in the fallopian tube of BRCA mutation carriers undergoing prophylactic salpingo-oophorectomy (32), whereas our study focused on sporadic HGSOC. As clinical studies have begun to investigate the utility and safety of salpingectomy in high-risk patients (33–35), it will be imperative to understand if metastasis to the fallopian tube occurs in the context of germline BRCA mutations. Lastly, the frequent observation of STIC detected after neoadjuvant treatment (occurring in 50% of all cases) could represent a late metastasis to a chemoresistant niche (36). Therefore, a better understanding of the cross-talk between cell types unique to intraepithelial fallopian tube metastases could be both relevant clinically and important biologically.